Ultomiris Infusion: Time, Cost, Protocol, Side Effects, Duration, Rate

Content:

• What is Ultomiris Infusion?
• Ultomiris Infusion Time
• Ultomiris Infusion Cost
• Ultomiris Infusion Protocol
• Ultomiris Infusion Side Effects
• Ultomiris Infusion Duration
• Ultomiris Infusion Rate

What is Ultomiris Infusion?

Ultomiris (ravulizumab) is a long-acting C5 complement inhibitor administered via intravenous (IV) infusion. It is prescribed for conditions such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). By inhibiting terminal complement activity, it prevents the destruction of red blood cells and related complications.

This medication offers extended dosing intervals compared to earlier treatments like Soliris, making it more convenient for long-term management of rare complement-mediated diseases. It is administered in a healthcare setting by trained professionals.

Ultomiris Infusion Time

The infusion time for Ultomiris depends on the patient’s weight and prescribed dose. Typically, it is infused over approximately 2 hours. The initial loading dose may take slightly longer, while maintenance doses are faster, especially after the first administration.

The infusion is usually done every 8 weeks for adults following the loading dose schedule. Careful monitoring during and after the infusion ensures patient safety and helps detect any adverse reactions early.

Ultomiris Infusion Cost

Ultomiris is an expensive treatment, with costs reaching up to $500,000–$600,000 per year in the United States, depending on dosage and insurance coverage. Each individual infusion can cost tens of thousands of dollars without financial assistance.

Insurance often covers a portion of the treatment, and manufacturer support programs may be available. Patients are encouraged to consult their healthcare provider or specialty pharmacy to explore cost-reduction options.

Ultomiris Infusion Protocol

The Ultomiris infusion protocol includes:

• Administration through a dedicated IV line by trained personnel.
• Pre-medication may be considered if there is a history of infusion reactions.
• Monitoring for at least one hour post-infusion.
• Initiating therapy with a loading dose, followed by maintenance doses every 8 weeks.

The protocol must be strictly followed as per physician direction, and any missed doses should be managed promptly to maintain therapeutic levels.

Ultomiris Infusion Side Effects

Common side effects of Ultomiris include:

• Headache
• Upper respiratory tract infections
• Fatigue
• Nausea

Serious side effects may include increased risk of meningococcal infection. All patients must be vaccinated against meningococcus before starting therapy. Immediate medical attention is required if symptoms such as fever, stiff neck, or confusion occur.

Ultomiris Infusion Duration

The total duration of treatment with Ultomiris is long-term and may span years depending on disease control and patient response. Each infusion appointment lasts around 2 hours, not including pre- and post-infusion monitoring time.

Because Ultomiris has a longer half-life, it allows for extended intervals between treatments compared to previous therapies, reducing treatment burden for patients.

Ultomiris Infusion Rate

The infusion rate of Ultomiris is weight-based and follows strict guidelines to prevent adverse reactions. Typically, it is administered over 2 hours at a rate adjusted according to the patient's weight category.

Healthcare professionals ensure the IV rate is controlled using infusion pumps and monitor vital signs throughout. Any adverse symptoms may require slowing or halting the infusion.